在新季中，Benji和Esther的古怪友谊令身边所有人更加困惑，而他们也更加努力地让自己融入洛杉矶的拜金文化和享乐文化。他们干着古怪的工作，应对着古怪的爱情生活，为追求社会地位不遗余力。本季的客座演员包括：Fran Drescher扮演Esther的母亲Mary，总是一副完美的贵妇形象；Natasha Leggero扮演事业成功、沉着冷静的女强人Nora，Esther在健身房里遇到她；Hana Mae Lee扮演一身哥特装扮的Gigi，喜欢疯狂聚会，Benji在音乐会上遇到她；Danny Pudi和Abby Elliott扮演夫妇Chris和Megan，他们原本非常愚钝，对什么都不感兴趣，但自从遇到性格古怪的Benji和Esther之后他们便兴奋起来；Nicole Sullivan扮演作家Becky，因为某种原因必须与Esther和Benji合作；Carmen Electra扮演一个美貌的神秘女人，她试图色诱Benji；Punam Patel扮演Esther六年前在演员培训班上结识的朋友Tara。Kay Cannon、Maz Jobrani、Andrew Santino、Seth Morris、Erik Griffin亦将参与演出。Chris D’Elia再次扮演Benji的哥哥Dean，Ginger Gonzaga再次扮演Benji的姐姐Alia，Edgar Blackmon再次扮演Benji和Esther的朋友Jeff，Nikki Glaser再次扮演Annette。

　　Former police detective Adrian Monk (Tony Shalhoub), whose photographic memory and amazing ability to piece together tiny clues made him a local legend, has suffered from intensified obsessive-compulsive disorder and a variety of phobias since the unsolved murder of his wife, Trudy, in 1997. Now on psychiatric leave from the San Francisco Police Department and working as a freelance detective/ consultant on difficult cases, Monk hopes to convince his former boss, Captain Leland Stottlemeyer (Ted Levine), to allow him to return to the force. Stottlemeyer, who wavered between admiration for Monk and annoyance at his eccentricities during the first season, is becoming more of a friend to Monk as the series develops, frequently calling him in to help, as much for Monk's benefit as for his own. However, he knows Monk's limitations as well as his strengths and may still harbor doubts about the wisdom of allowing Monk to carry a gun or subdue a perpetrator. Stottlemeyer's second-in-command, Lieutenant Randall Disher (Jason Gray-Stanford), also seems to be developing both admiration and compassion for the man he once labeled "the defective detective."
　　Despite flaws and inadequacies all around, the three are becoming an increasingly effective team, with additional help from Monk's personal assistant. From the double-episode pilot through the first half of season three, Monk was aided by his nurse, Sharona Fleming (Bitty Schram). But in the tenth episode of the third season, Sharona was replaced by a new assistant, Natalie Teeger (Traylor Howard). Like Sharona, a divorcee with a son named Benjy, Natalie is a single parent, a widow with a daughter named Julie (Emmy Clarke). Unlike Sharona, Natalie is not a nurse but a former bartender with a fresh perspective on "Mr. Monk," as she still addresses her new boss.

　　妻子的死让警探艾德里安（托尼·夏尔赫布 Tony Shalhoub 饰）的生活跌落到了谷底，不久之后，常常陷入悲痛之中的艾德里安患上了强迫症。强迫症令艾德里安在警局里无处容身，很快，他便丢掉了工作，成为了无业游民。
　　为了生存，艾德里安必须赚钱，就这样，一家私人侦探所成立了。艾德里安雇佣了护士莎罗纳（Bitty Schram 饰）为他打理日常生活，自己则靠着出色的逻辑推理能力和过目不忘的神奇本领解决了一件又一件离奇案件。之后，艾德里安结识了名为娜塔莉（特蕾勒·霍华德 Traylor Howard 饰）的单身母亲，两人之间十分投缘。随着时间的推移，丧妻之痛由浓转淡，但妻子被害一案的前因后果却依然深藏在迷雾之中，艾德里安能够依靠自己的力量破解此案揭开心结吗？

　　该剧改编自《喜鹊谋杀案》的直接续作。
　　Susan已经离开出版社，和交往多年的男友Andreas搬到了克里特岛居住，但一起谋杀案的阴影扰乱了她的美好生活。英国的一家乡村酒店在八年前发生了一起谋杀案，Alan Conway在参观了这家酒店后，根据发生的事情写了一本小说。帮助经营这家酒店的年轻女子Cecily Treherne读到了这本书，认为警方抓错了人。如今她消失了。
　　Susan能揭开书中隐藏的秘密，并在为时已晚之前找到Cecily吗？

　　Anthony Bourdain visits country's and delves into political issues as well as indigenous food and culture.

　　Anthony Bourdain visits country's and delves into political issues as well as indigenous food and culture.