House医生和他经过精挑细选的专家组成的团队，最拿手的是诊断重症病人和处理神秘和危机的不明疾病。只有最严重和从未听说过的病症才会由他们接手。他们负责诊断，判断是否合法，尽全力营救病人的生命。但是在这部电视剧里，house和他的团队仍然显示了他们乐观搞笑的一面，爆出了不少笑料。

　　Joey begins her first day at Worthington University where she is struggling in her beginners writing class taught by Professor David Wilder who criticizes her first essay about her and Dawson. Audrey Liddell, Joey's brash new roommate from Beverly Hills, proves to be more of an annoyance than a friend with her wild and crazy personality. Dawson, who's continuing his studies at USC with an internship in Hollywood, begins his job on a shaky start when he meets Todd Carr, an arrogant, egocentric, hack film director who gives Dawson a hard time. Meanwhile, Jen pays Pacey a visit, who's lying low as he docks his yacht in Boston Harbor after sailing away the summer. At nearby Boston Bay College, Jen and Jack are invited to their first fraternity party. They persuade Joey to come along with Audrey who seems to get along with Jen and Jack, much to Joey's surprise. Also, Jen meets Charlie, a bass player. She is rude to him, insulting him away, but deep inside feels strongly attracted to him.

　　Eli苦口婆心地劝说Alicia启动参选州检察官的宣传活动，但Alicia固执地拒绝了。与此同时，Diane考虑以合伙人身份加盟Florrick/Agos事务所，但一场内部危机很可能在她加盟之前就毁掉这家事务所。
　　本季开始的时候，Eli竭力劝说（苦苦哀求）Alicia参选州检察官，但Alicia一直拒绝（你将看到她异常顽固的一面），由此产生了该剧不常见的喜剧效果。

　　侦探小说作家Richard Castle (内森·菲利安 Nathan Fillion 饰)什么都不缺:名利、英俊的外表、崇拜者等，但他却对这种生活感到厌倦，处于事业上的瓶颈。在家又被过气演员母亲Martha(Susan Sullivan饰)和十五岁但人细鬼大的女儿Alexis(莫莉·奎恩 Molly C. Quinn 饰)盯紧。自从纽约刑警调查员Kate Beckett (斯坦娜·卡蒂克 Stana Katic 饰)找上他协助调查一连串的凶杀案开始。Richard开始以他的侦探头脑帮助Kate破案。而两人在争执和磨擦中建立默契，甚至感情和爱情……

　　在这部里“亚特兰蒂斯”这个古人的秘密开始被发现，《星际之门亚特兰蒂斯》中的Elizabeth Weir指挥官将开始登场，并主导大局。
　　这部剧才是真正《星际之门亚特兰蒂斯》的前一部。

　　《危险性游戏》围绕着曼彻斯特学院中的精英学生展开。在这里，冷血无情的继兄妹卡罗琳和卢西恩会不惜一切代价，维持他们在残酷的社会等级制度中的领头羊地位。在一起残忍的欺凌事件威胁到整个希腊式生活之后，他们将不择手段维护自己的权力和名声，即使这意味着勾引副总统的女儿。

　　在繁华的20世纪80年代纽约，木偶艺人文森特（本尼迪克特·康伯巴奇 Benedict Cumberbatch 饰）的世界在儿子埃德加失踪的那一刻彻底崩塌。他沉浸在无尽的绝望和自责中，每个日夜都在苦苦寻找那个曾经欢声笑语的家。
　　儿子埃德加画下的蓝色怪物木偶埃里克，成了文森特心中唯一的慰藉。他坚信，只要埃里克能够登上电视屏幕，那个失踪的、曾给他带来无尽欢乐的儿子就会回到他的身边。然而，在追求这个信念的道路上，文森特的疯狂行为逐渐让他失去了家人、同事，甚至是那些曾试图伸出援手的侦探。
　　在无尽的孤独和黑暗中，埃里克成为了文森特唯一的盟友，陪伴他踏上了寻找儿子的漫长征途。这是一场充满爱与绝望的旅程，让人不禁为文森特的坚持而动容，也为那个未曾归来的小小身影而祈祷。

　　Set and filmed in Liverpool, This City is Ours is the story of Michael, a man who for all of his adult life has been involved in organised crime, working for his friend and the gang leader Ronnie. When Ronnie begins to hint at retirement, Michael too begins to imagine another life. Because, for the first time in his life, Michael is in love. For the first time in his life, he sees beyond the day-to-day, he sees a future: something to win and something to lose - Diana.
　　This City is Ours is the story of Michael and Diana's love affair, set against the disintegration of Michael’s crime gang. For years, together with Ronnie, Michael has successfully been bringing cocaine into the City and beyond, directly from Columbia; but when a shipment goes missing, he knows their Kingdom is under attack.
　　This City is Ours explores what happens when Ronnie’s son Jamie decides he wants to inherit their kingdom and that there is no longer a place for Michael at the table. Both Michael and Jamie have bold ideas to modernise the gang and they will battle for control of it. But Michael’s biggest battle will be to save the woman he loves and the child he has always wanted.
　　This is a story about family, and love destroyed and corrupted by ambition, pride and greed. It’s a story about power: what we will do to secure and keep it.

　　本剧继续通过荧幕呈现James Herriot创作的故事，观众将回到Darrowby，重新加入不拘一格、备受喜爱的Skeldale大家庭，以及1940年代生活在约克郡山谷的农场主、动物和乡亲们。