女友玛丽（戴安·梅尔 Dina Meyer 饰）和同事的接连死亡让FBI探员杰克（西尔维斯特·史泰龙 Sylvester Stallone 饰）陷入了绝望和崩溃之中，因为他很清楚的知道，这个冷酷的杀手是冲着他来的，痛苦而又无处发泄的杰克只得向酒精寻求帮助。亨德里克斯（查尔斯·达顿 Charles Dutton 饰）不忍心看到好友就此堕落，他建议杰克戒酒。
　　就这样，杰克来到了位于怀俄明荒原之中的戒酒中心，在这里，他结识了助理汉克（汤姆·贝伦杰 Tom Berenger 饰）和护士珍妮（波利·沃克 Polly Walker 饰）。一场可怕的暴风雪破坏了戒酒中心的电路和赖以取暖的锅炉，在黑暗和寒冷之中，杰克要面对的除了自己的心魔，还有潜藏在阴影里的凶手。

　　麦可(狄恩肯恩饰)在路上搭载了年轻性感的正妹(克莉丝汀波森饰)，麦可原先认为漫漫公路有正妹相伴艳福不浅，自以为遇上了豔遇的他，却不知道自己即将陷入一连串的阴谋及杀机，一趟没有终点的旅程即将展开…
　　故事描述一个男人在路途中载了一位年轻的女人，原来只是好心借人搭便车，结果男主人公却发现自己陷入了一场可怕的午夜梦魇……
　　If she looks too good to be true, then she absolutely is. Just ask Michael Anderson (Dean Cain), a gullible film editor who picks up a sexy young hitchhiker (Christie Burson) in the Arizona desert. After the most thrilling one night stand of his life, Michael becomes embroiled in a twisted love con involving a sadistic crime boss (Michael Madsen), a lonely henchman, and a thieving bank manager. Trust isn't just a bitch, it's a dirty little trick!
　　A crime bosss money is missing and he wants it back by any ay means. The beautiful hitchhiker has it and wants to make the getaway.
　　Alexander "Sasha" Shulgin is the scientist behind more than 200 psychedelic compounds - including MDMA, more commonly known as Ecstasy. Considered to be one of the greatest chemists of the 20th century, Sasha's vast array of discoveries have had a profound impact in the field of psychedelic research, making him a subject of fascination and controversy among fellow scientists and a folk hero to recreational users of psychedelics. Dirty Pictures uncovers the lifework of Dr. Shulgin and takes  viewers inside his Northern California home where he lives with his wife of 40 years and continues to carry out experiments in a makeshift laboratory. Director étienne Sauret likewise delves into the broader world of psychedelic research - where the fields of chemistry, neuroscience and philosophy intersect - and investigates whether or not this particular field could aid in solving the deepest mysteries of the human mind.